Heterocyclic Synthesis with Nitriles: A Novel Synthesis of Some Thiophene and Thieno[2,3-d]pyrimidine Derivatives, II [1]
نویسندگان
چکیده
2-Amino-3-functionally substituted thiophene de rivatives are important intermediates to the phar maceutically important thieno[2,3-d]pyrimidines [2]. These thiophene derivatives were available from the procedures published by K. Gewald [3, 4] via either the reaction of a-methylene ketones with active methylene nitriles in presence of elementary sulphur of from a-mercaptoketones and active methylene nitriles. In continuation of a program aiming to develop new simple procedures for the synthesis of azoles, azines and their condensed derivatives utilizing labo ratory available starting materials [5, 6 ], we have re cently reported [1 ] a novel and simple synthesis of
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